Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

The conformational state of the activation loop (A-loop) is pivotal for the activity of most protein kinases. Hence, the characterization of the conformational dynamics of the A-loop is important to increase our understanding of the molecular processes related to diseases and to support the discover...

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Bibliographic Details
Main Authors: Zahra Musavizadeh, Alessandro Grottesi, Giulia Guarguaglini, Alessandro Paiardini
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
Aurora-A
molecular dynamics simulation
activation loop
conformational dynamics
Online Access:https://www.mdpi.com/2218-273X/11/4/567

Internet

https://www.mdpi.com/2218-273X/11/4/567

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