LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells

LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultur...

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Bibliographic Details
Main Authors: Orapan Sripichai, Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Tiwaporn Nualkaew, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Hematology Reports
Subjects:
thalassemia, erythroid, fetal hemoglobin, LSD1, RN-1
Online Access:https://www.pagepress.org/journals/index.php/hr/article/view/9215

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https://www.pagepress.org/journals/index.php/hr/article/view/9215

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