Genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway: An experimental model for environmental carcinogenesis and pharmacological research

Genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway: An experimental model for environmental carcinogenesis and pharmacological research

Polycyclic aromatic hydrocarbons (PAHs), including the Group 1 human carcinogen benzo[a]pyrene (BaP), are produced by the incomplete combustion of organic matter and thus are present in tobacco smoke, charbroiled food and diesel exhaust. The nematode Caenorhabditis elegans is an established model or...

Full description

Bibliographic Details
Main Authors: Yuzhi Chen, Yang Jiang, Nirujah Sarvanantharajah, Orapan Apirakkan, Mengqi Yang, Alena Milcova, Jan Topinka, Vincenzo Abbate, Volker M. Arlt, Stephen R. Stürzenbaum
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Environment International
Subjects:
Caenorhabditis elegans
CYP1A1
CYP1A2
Benzo[a]pyrene
RNAseq
DNA adducts
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024007736

Internet

http://www.sciencedirect.com/science/article/pii/S0160412024007736

Similar Items