The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Abstract Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers. We have identified for the first time, tagSNPs in the genes for extracellular matrix proteins, aggrecan and fibu...

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Bibliographic Details
Main Authors: Yasmin, Raya Al Maskari, Carmel M. McEniery, Sarah E. Cleary, Ye Li, Keith Siew, Nichola L. Figg, Ashraf W. Khir, John R. Cockcroft, Ian B. Wilkinson, Kevin M. O’Shaughnessy
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25851-5

Internet

https://doi.org/10.1038/s41598-018-25851-5

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