Evaluating the Influence of a G-Quadruplex Prone Sequence on the Transactivation Potential by Wild-Type and/or Mutant P53 Family Proteins through a Yeast-Based Functional Assay

Evaluating the Influence of a G-Quadruplex Prone Sequence on the Transactivation Potential by Wild-Type and/or Mutant P53 Family Proteins through a Yeast-Based Functional Assay

P53, P63, and P73 proteins belong to the P53 family of transcription factors, sharing a common gene organization that, from the P1 and P2 promoters, produces two groups of mRNAs encoding proteins with different N-terminal regions; moreover, alternative splicing events at C-terminus further contribut...

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Bibliographic Details
Main Authors: Paola Monti, Vaclav Brazda, Natália Bohálová, Otília Porubiaková, Paola Menichini, Andrea Speciale, Renata Bocciardi, Alberto Inga, Gilberto Fronza
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Genes
Subjects:
P53 family
yeast
G-quadruplex (G4) prone sequence
wild-type and mutant P53/P63 proteins
transactivation potential
Online Access:https://www.mdpi.com/2073-4425/12/2/277

Internet

https://www.mdpi.com/2073-4425/12/2/277

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