Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection

Abstract Background Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progressive neurodegeneration and cognitive decline. Establi...

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Bibliographic Details
Main Authors: Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa, Sean Ott, Blythe P. Durbin-Johnson, Ashok R. Dinasarapu, Andrea Gompers, John H. Morrison, Smita S. Iyer
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Neuroinflammation
Subjects:
Rhesus macaque
SHIV
RNA-seq
Neuroinflammation
Neuro AIDS
T cells
Online Access:https://doi.org/10.1186/s12974-022-02610-y

Internet

https://doi.org/10.1186/s12974-022-02610-y

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