SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral DNA synthesis by v...

Full description

Bibliographic Details
Main Authors: Siqi Hu, Jian Li, Fengwen Xu, Shan Mei, Yann Le Duff, Lijuan Yin, Xiaojing Pang, Shan Cen, Qi Jin, Chen Liang, Fei Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4489885?pdf=render

Internet

http://europepmc.org/articles/PMC4489885?pdf=render

Similar Items