Metabolite profile of a mouse model of Charcot–Marie–Tooth type 2D neuropathy: implications for disease mechanisms and interventions

Metabolite profile of a mouse model of Charcot–Marie–Tooth type 2D neuropathy: implications for disease mechanisms and interventions

Charcot–Marie–Tooth disease encompasses a genetically heterogeneous class of heritable polyneuropathies that result in axonal degeneration in the peripheral nervous system. Charcot–Marie–Tooth type 2D neuropathy (CMT2D) is caused by dominant mutations in glycyl tRNA synthetase (GARS). Mutations in t...

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Bibliographic Details
Main Authors: Preeti Bais, Kirk Beebe, Kathryn H. Morelli, Meagan E. Currie, Sara N. Norberg, Alexei V. Evsikov, Kathy E. Miers, Kevin L. Seburn, Velina Guergueltcheva, Ivo Kremensky, Albena Jordanova, Carol J. Bult, Robert W. Burgess
Format: Article
Language:English
Published: The Company of Biologists 2016-07-01
Series:Biology Open
Subjects:
Peripheral neuropathy
Spinal cord
Sciatic nerve
Metabolomics
Mass Spectrometry
tRNA synthetase
Online Access:http://bio.biologists.org/content/5/7/908

Internet

http://bio.biologists.org/content/5/7/908

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