The role of microglia in neuronal and cognitive function during high altitude acclimatization

The role of microglia in neuronal and cognitive function during high altitude acclimatization

Abstract Due to their interactions with the neurovasculature, microglia are implicated in maladaptive responses to hypobaric hypoxia at high altitude (HA). To explore these interactions at HA, pharmacological depletion of microglia with the colony-stimulating factor-1 receptor inhibitor, PLX5622, wa...

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Bibliographic Details
Main Authors: Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D. Stimpson, Tara Barvir, Nathan P. Cramer, Daniel P. Perl, Guoqiang Yu, Caroline A. Browne, Dara L. Dickstein, Zygmunt Galdzicki
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
High altitude
Microglia
Neurovasculature
Microglial heterogeneity
Online Access:https://doi.org/10.1038/s41598-024-69694-9

Internet

https://doi.org/10.1038/s41598-024-69694-9

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