Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

<b>Background</b>: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. <b>Aim</b>: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose ratio (C<sub>0</su...

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Hlavní autoři: Nikola Stefanović, Radmila Veličković-Radovanović, Katarina Danković, Ivan Pavlović, Aleksandra Catić-Đorđević, Jelena Bašić, Milena Despotović, Tatjana Jevtović-Stoimenov, Branka Mitić, Tatjana Cvetković
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2021-11-01
Edice:Pharmaceutics
Témata:
intrapatient variability
kidney transplantation
CYP3A5 genotype
tacrolimus
therapeutic drug monitoring
On-line přístup:https://www.mdpi.com/1999-4923/13/11/1970

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https://www.mdpi.com/1999-4923/13/11/1970

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