TRAIL-Based Therapies Efficacy in Pediatric Bone Tumors Models Is Modulated by TRAIL Non-Apoptotic Pathway Activation via RIPK1 Recruitment

TRAIL-Based Therapies Efficacy in Pediatric Bone Tumors Models Is Modulated by TRAIL Non-Apoptotic Pathway Activation via RIPK1 Recruitment

Despite advances in clinical management, osteosarcoma and Ewing sarcoma, the two most frequent malignant primary bone tumors at pediatric age, still have a poor prognosis for high-risk patients (i.e., relapsed or metastatic disease). Triggering a TRAIL pro-apoptotic pathway represents a promising th...

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Bibliographic Details
Main Authors: Régis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Bénédicte Brounais-Le Royer, Franck Verrecchia, Françoise Rédini, Romain Guiho
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
TNF-related apoptosis inducing ligand (TRAIL)
TRAIL-based therapies
osteosarcoma
Ewing sarcoma
pediatric bone tumor
resistance
Online Access:https://www.mdpi.com/2072-6694/14/22/5627

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https://www.mdpi.com/2072-6694/14/22/5627

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