Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Abstract Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor...

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Bibliographic Details
Main Authors: SiSi Li, YangFan Qi, JiaChuan Yu, YuChao Hao, Bin He, MengJuan Zhang, ZhenWei Dai, TongHui Jiang, SuYi Li, Fang Huang, Ning Chen, Jing Wang, MengYing Yang, DaPeng Liang, Fan An, JinYao Zhao, WenJun Fan, YuJia Pan, ZiQian Deng, YuanYuan Luo, Tao Guo, Fei Peng, ZhiJie Hou, ChunLi Wang, FeiMeng Zheng, LingZhi Xu, Jie Xu, QingPing Wen, BiLian Jin, Yang Wang, Quentin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00905-3

Internet

https://doi.org/10.1038/s41392-022-00905-3

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