Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts

Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts

The mechanism of action of elisidepsin (PM02734, Irvalec®) is assumed to involve membrane permeabilization via attacking lipid rafts and hydroxylated lipids. Here we investigate the role of hypoxia in the mechanism of action of elisidepsin. Culturing under hypoxic conditions increased the half-maxim...

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Bibliographic Details
Main Authors: Anna Király, Tímea Váradi, Tímea Hajdu, Ralph Rühl, Carlos M. Galmarini, János Szöllősi, Peter Nagy
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Marine Drugs
Subjects:
elisidepsin
lipid rafts
hydroxylated lipids
fatty acid 2-hydroxylase
cooperative binding
membrane permeabilization
Online Access:http://www.mdpi.com/1660-3397/11/12/4858

Internet

http://www.mdpi.com/1660-3397/11/12/4858

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