Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Abstract Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences. Methods A...

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Bibliographic Details
Main Authors: Memoona Rashid, Muhammad Sarfraz, Mosab Arafat, Amjad Hussain, Nasir Abbas, Muhammad Waqas Sadiq, Muhammad Fawad Rasool, Nadeem Irfan Bukhari
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
Lisinopril
PBPK
Pediatric
PK-Sim MoBI®
Area under the curve
Online Access:http://link.springer.com/article/10.1186/s40360-020-00429-y

Internet

http://link.springer.com/article/10.1186/s40360-020-00429-y

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