Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1

Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1

Objectives Cellular senescence is strongly associated with fibrosis and tumorigenesis. However, whether the epithelium of oral submucous fibrosis (OSF) undergoes premature senescence remains unclear. This study investigates the roles of senescent epithelial cells in OSF. Methods The immunohistochemi...

Full description

Bibliographic Details
Main Authors:	Zijia Wang, Ying Han, Ying Peng, Shuhui Shao, Huanquan Nie, Kun Xia, Haofeng Xiong, Tong Su
Format:	Article
Language:	English
Published:	PeerJ Inc. 2023-04-01
Series:	PeerJ
Subjects:	Oral submucous fibrosis Epithelial cell Cellular senescence Senescence-associated secretory phenotype Transforming growth factor β
Online Access:	https://peerj.com/articles/15158.pdf

Similar Items

Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression
by: Yinhao Wang, et al.
Published: (2022-12-01)

MAPKs in the early steps of senescence implemEMTation
by: Carlos Anerillas, et al.
Published: (2023-03-01)

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
by: Blake Ouvrier, et al.
Published: (2024-02-01)

Recent advances in senescence-associated secretory phenotype and osteoporosis
by: Haonan Fan, et al.
Published: (2024-02-01)

Cellular senescence and the tumour microenvironment
by: Masaki Takasugi, et al.
Published: (2022-09-01)

Senescent Microglia: The Key to the Ageing Brain?
by: Eleanor K. Greenwood, et al.
Published: (2021-04-01)

Radiation-induced senescence: therapeutic opportunities
by: Jae Ho Kim, et al.
Published: (2023-01-01)

Expression of Senescence-Associated Secretory Phenotype in Senescent Gingival Fibroblasts
by: Sangim Lee
Published: (2023-06-01)

Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
by: Shenghui Zhou, et al.
Published: (2022-11-01)

Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis
by: Priyanka Banerjee, et al.
Published: (2023-02-01)

Linking ABCC6 Deficiency in Primary Human Dermal Fibroblasts of PXE Patients to p21-Mediated Premature Cellular Senescence and the Development of a Proinflammatory Secretory Phenotype
by: Janina Tiemann, et al.
Published: (2020-12-01)

Flavonoids in Skin Senescence Prevention and Treatment
by: Anna Domaszewska-Szostek, et al.
Published: (2021-06-01)

Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis
by: Szymon Rutecki, et al.
Published: (2022-07-01)

Giant Multinucleated Cells in Aging and Senescence—An Abridgement
by: Malgorzata Kloc, et al.
Published: (2022-07-01)

NAD+ metabolism controls inflammation during senescence
by: Timothy Nacarelli, et al.
Published: (2019-07-01)

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation
by: Angelica Giuliani, et al.
Published: (2023-11-01)

Editorial: Cellular senescence in diabetes: from markers to mechanisms and therapies
by: Cristina Aguayo-Mazzucato, et al.
Published: (2023-12-01)

Lipopolysaccharides and Cellular Senescence: Involvement in Atherosclerosis
by: Kaori Suzuki, et al.
Published: (2022-09-01)

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
by: Angel Cayo, et al.
Published: (2023-05-01)

Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells
by: Christine Hansel, et al.
Published: (2021-06-01)

Cellular Senescence in Hepatocellular Carcinoma: The Passenger or the Driver?
by: Xiurong Cai, et al.
Published: (2022-12-01)

Extracellular Vesicles as New Players in Cellular Senescence
by: Lorena Urbanelli, et al.
Published: (2016-08-01)

TP53 mutation‐related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles
by: Yu‐Yan Chen, et al.
Published: (2023-05-01)

Cellular senescence and wound healing in aged and diabetic skin
by: Arisa Kita, et al.
Published: (2024-02-01)

Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells
by: Christine Hansel, et al.
Published: (2020-05-01)

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy
by: Markus Schosserer, et al.
Published: (2017-11-01)

Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing
by: Maria Patrizia Mongiardi, et al.
Published: (2021-01-01)

p21 induces a senescence program and skeletal muscle dysfunction
by: Davis A. Englund, et al.
Published: (2023-01-01)

Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway
by: Jian-Wei Zhang, et al.
Published: (2023-12-01)

DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
by: Xinna Wu, et al.
Published: (2023-11-01)

Senescence-associated secretory phenotype and its impact on oral immune homeostasis
by: Ziqi Yue, et al.
Published: (2022-10-01)

Altered p16<sup>Ink4a</sup>, IL-1β, and Lamin b1 Protein Expression Suggest Cellular Senescence in Deep Endometriotic Lesions
by: Helena Malvezzi, et al.
Published: (2022-02-01)

Bufei Yishen Formula Inhibits the Cell Senescence in COPD by Up-Regulating the ZNF263 and Klotho Expression
by: Wang W, et al.
Published: (2023-04-01)

Aging Fibroblasts Adversely Affect Extracellular Matrix Formation via the Senescent Humoral Factor Ependymin-Related Protein 1
by: Kento Takaya, et al.
Published: (2022-11-01)

An unbiased proteomics approach to identify the senescence-associated secretory phenotype of human bone marrow-derived mesenchymal stem cells
by: Rebekah M. Samsonraj, et al.
Published: (2023-06-01)

Senescent AECⅡ and the implication for idiopathic pulmonary fibrosis treatment
by: Tingwei Zhang, et al.
Published: (2022-11-01)

Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
by: Julia Kallenbach, et al.
Published: (2022-12-01)

Biological Effects of “Inflammageing” on Human Oral Cells: Insights into a Potential Confounder of Age-Related Diseases
by: Elli Alexakou, et al.
Published: (2023-12-01)

HELLS modulates the stemness of intrahepatic cholangiocarcinoma through promoting senescence-associated secretory phenotype
by: Xiaojing Du, et al.
Published: (2023-01-01)

HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence
by: Konstantinos Sofiadis, et al.
Published: (2021-06-01)