Early antiretroviral therapy and its impact on natural killer cell dynamics in HIV-1 infected men who have sex with men: a cross-sectional pilot study evaluating the impact of early ART initiation on NK cell perturbation in HIV infection

Early antiretroviral therapy and its impact on natural killer cell dynamics in HIV-1 infected men who have sex with men: a cross-sectional pilot study evaluating the impact of early ART initiation on NK cell perturbation in HIV infection

ABSTRACTPhenotypic changes and functional impairment of natural killer (NK) cells occur early in HIV-1 infection. Antiretroviral therapy (ART) effectively restores CD4+ T cell counts and suppresses HIV-1 to undetectable levels. The role and efficacy of immediate ART initiation in mitigating NK cell...

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Bibliographic Details
Main Authors: Matrona Akiso, Daniel Muema, Robert Langat, Kewreshini K. Naidoo, Geoffrey Oino, Gaudensia Mutua, Christina Thobakgale, Daniel Ochiel, Kundai Chinyenze, Omu Anzala, Marianne W. Mureithi
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
acute HIV-1 infection
ART
innate immunity
natural killer cells; MSMs
seroconversion
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03570-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03570-23

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