The Structural Basis of <i>Mycobacterium tuberculosis</i> RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding

The Structural Basis of <i>Mycobacterium tuberculosis</i> RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding

Tuberculosis (TB), caused by the <i>Mycobacterium tuberculosis</i> infection, continues to be a leading cause of morbidity and mortality in developing countries. Resistance to the first-line anti-TB drugs, isoniazid (INH) and rifampicin (RIF), is a major drawback to effective TB treatmen...

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Bibliographic Details
Main Authors: Arnold Amusengeri, Asifullah Khan, Özlem Tastan Bishop
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
drug resistance
mutations
rifampicin
<i>rpoB</i>
molecular dynamics simulations
dynamic residue network analysis
Online Access:https://www.mdpi.com/1420-3049/27/3/885

Internet

https://www.mdpi.com/1420-3049/27/3/885

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