Identification of a lichen depside polyketide synthase gene by heterologous expression in Saccharomyces cerevisiae

Identification of a lichen depside polyketide synthase gene by heterologous expression in Saccharomyces cerevisiae

Lichen-forming fungi produce a variety of secondary metabolites including bioactive polyketides. Advances in DNA and RNA sequencing have led to a growing database of new lichen gene clusters encoding polyketide synthases (PKS) and associated ancillary activities. Definitive assignment of a PKS gene...

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Bibliographic Details
Main Authors: James T. Kealey, James P. Craig, Philip J. Barr
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Metabolic Engineering Communications
Subjects:
Lichen
Polyketide synthase
Synthetic biology
Heterologous expression
Depside
Natural product
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030121000122

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http://www.sciencedirect.com/science/article/pii/S2214030121000122

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