A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3

A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3

Abstract Background Alzheimer’s disease (AD) is characterized by cognitive dysfunction and amyloid plaques composed of the amyloid-beta peptide (Aβ). APOE is the greatest genetic risk for AD with APOE4 increasing risk up to ~ 15-fold compared to APOE3. Evidence suggests that levels and lipidation of...

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Bibliographic Details
Main Authors: Ana C. Valencia-Olvera, Deebika Balu, Shreya Bellur, Thomas McNally, Yaseen Saleh, Don Pham, Shivesh Ghura, Jason York, Jan O. Johansson, Mary Jo LaDu, Leon Tai
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
apoE
CS-6253
EFAD mice
Online Access:https://doi.org/10.1186/s13195-023-01353-z

Internet

https://doi.org/10.1186/s13195-023-01353-z

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