Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models
A substantial proportion of heart failure patients have a preserved left ventricular (LV) ejection fraction (HFpEF). This condition carries a high burden of morbidity and mortality and has limited therapeutic options. left ventricular pressure overload leads to an increase in myocardial collagen con...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1032034/full |
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| author | Jonathan Weissmann Christopher J. Charles Christopher J. Charles Christopher J. Charles A. Mark Richards A. Mark Richards Choon Hwai Yap Gil Marom |
| author_facet | Jonathan Weissmann Christopher J. Charles Christopher J. Charles Christopher J. Charles A. Mark Richards A. Mark Richards Choon Hwai Yap Gil Marom |
| author_sort | Jonathan Weissmann |
| collection | DOAJ |
| description | A substantial proportion of heart failure patients have a preserved left ventricular (LV) ejection fraction (HFpEF). This condition carries a high burden of morbidity and mortality and has limited therapeutic options. left ventricular pressure overload leads to an increase in myocardial collagen content, causing left ventricular stiffening that contributes to the development of heart failure patients have a preserved left ventricular ejection fraction. Although several heart failure patients have a preserved left ventricular ejection fraction models have been developed in recent years to aid the investigation of mechanical alterations, none has investigated different phenotypes of the disease and evaluated the alterations in material properties. In this study, two similar healthy swine were subjected to progressive and prolonged pressure overload to induce diastolic heart failure characteristics, providing a preclinical model of heart failure patients have a preserved left ventricular ejection fraction. Cardiac magnetic resonance imaging (cMRI) scans and intracardiac pressures were recorded before and after induction. In both healthy and disease states, a corresponding finite element (FE) cardiac model was developed via mesh morphing of the Living Heart Porcine model. The material properties were derived by calibrating to its passive and active behavior. The change in the passive behavior was predominantly isotropic when comparing the geometries before and after induction. Myocardial thickening allowed for a steady transition in the passive properties while maintaining tissue incompressibility. This study highlights the importance of hypertrophy as an initial compensatory response and might also pave the way for assessing disease severity. |
| first_indexed | 2024-04-12T13:36:59Z |
| format | Article |
| id | doaj.art-f525d8b73ffc4d648d1e0cd735a63b5b |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T13:36:59Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f525d8b73ffc4d648d1e0cd735a63b5b2022-12-22T03:30:59ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10320341032034Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine modelsJonathan Weissmann0Christopher J. Charles1Christopher J. Charles2Christopher J. Charles3A. Mark Richards4A. Mark Richards5Choon Hwai Yap6Gil Marom7Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, IsraelDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeCardiovascular Research Institute, National University of Singapore, Singapore, SingaporeChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, New ZealandCardiovascular Research Institute, National University of Singapore, Singapore, SingaporeChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, New ZealandDepartment of Bioengineering, Imperial College London, London, United KingdomSchool of Mechanical Engineering, Tel Aviv University, Tel Aviv, IsraelA substantial proportion of heart failure patients have a preserved left ventricular (LV) ejection fraction (HFpEF). This condition carries a high burden of morbidity and mortality and has limited therapeutic options. left ventricular pressure overload leads to an increase in myocardial collagen content, causing left ventricular stiffening that contributes to the development of heart failure patients have a preserved left ventricular ejection fraction. Although several heart failure patients have a preserved left ventricular ejection fraction models have been developed in recent years to aid the investigation of mechanical alterations, none has investigated different phenotypes of the disease and evaluated the alterations in material properties. In this study, two similar healthy swine were subjected to progressive and prolonged pressure overload to induce diastolic heart failure characteristics, providing a preclinical model of heart failure patients have a preserved left ventricular ejection fraction. Cardiac magnetic resonance imaging (cMRI) scans and intracardiac pressures were recorded before and after induction. In both healthy and disease states, a corresponding finite element (FE) cardiac model was developed via mesh morphing of the Living Heart Porcine model. The material properties were derived by calibrating to its passive and active behavior. The change in the passive behavior was predominantly isotropic when comparing the geometries before and after induction. Myocardial thickening allowed for a steady transition in the passive properties while maintaining tissue incompressibility. This study highlights the importance of hypertrophy as an initial compensatory response and might also pave the way for assessing disease severity.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1032034/fullheart failure with preserved ejection fractionphenotypesfinite element analysiscomputational modellingmaterial propertiesanimal modeling |
| spellingShingle | Jonathan Weissmann Christopher J. Charles Christopher J. Charles Christopher J. Charles A. Mark Richards A. Mark Richards Choon Hwai Yap Gil Marom Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models Frontiers in Bioengineering and Biotechnology heart failure with preserved ejection fraction phenotypes finite element analysis computational modelling material properties animal modeling |
| title | Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models |
| title_full | Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models |
| title_fullStr | Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models |
| title_full_unstemmed | Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models |
| title_short | Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models |
| title_sort | material property alterations for phenotypes of heart failure with preserved ejection fraction a numerical study of subject specific porcine models |
| topic | heart failure with preserved ejection fraction phenotypes finite element analysis computational modelling material properties animal modeling |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1032034/full |
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