AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells

AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells

Previously, we discovered that 1-(3,5-dimethoxyphenyl)-3-(4-(3-methoxyphenoxy)-2-((4-morpholinophenyl)amino)pyrimidin-5-yl)urea (AKF-D52), a synthetic phenoxypyrimidine urea derivative, acts as a growth inhibitor of various cancer cell types. In this study, we elucidated the antiproliferative proper...

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Bibliographic Details
Main Authors: Hyo-Sun Gil, Jeong-Hun Lee, Ahmed K. Farag, Ahmed H. E. Hassan, Kyung-Sook Chung, Jung-Hye Choi, Eun-Joo Roh, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
AKF-D52
non-small cell lung cancer (NSCLC)
apoptosis
autophagy
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2072-6694/13/22/5849

Internet

https://www.mdpi.com/2072-6694/13/22/5849

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