Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-γ/LXR-α/ABCA1 in macrophages

Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-γ/LXR-α/ABCA1 in macrophages

Abstract Background Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of the present study was to explore the association between circulating sP...

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Bibliographic Details
Main Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang, Weihua Li
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Translational Medicine
Subjects:
Group IIA secretory phospholipase A2
High-density lipoprotein cholesterol
ATP-binding cassette A1
Cholesterol efflux
Peroxisome proliferator-activated receptor
Online Access:https://doi.org/10.1186/s12967-021-03151-3

Internet

https://doi.org/10.1186/s12967-021-03151-3

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