Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Abstract Background Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell resp...

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Bibliographic Details
Main Authors: Carmela De Santo, Paul Cheng, Andrew Beggs, Sharon Egan, Alberto Bessudo, Francis Mussai
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Hematology & Oncology
Subjects:
Arginase
Melanoma
Immunotherapy
Metabolism
BCT-100
Online Access:http://link.springer.com/article/10.1186/s13045-018-0612-6

Internet

http://link.springer.com/article/10.1186/s13045-018-0612-6

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