Development of Capillary Zone Electrophoresis Method for the Simultaneous Separation and Quantification of Metformin and Pioglitazone in Dosage Forms; and Comparison with HPLC Method

Development of Capillary Zone Electrophoresis Method for the Simultaneous Separation and Quantification of Metformin and Pioglitazone in Dosage Forms; and Comparison with HPLC Method

A capillary zone electrophoretic (CZE) method was developed, validated, and applied for the assay of metformin (MET) and pioglitazone (PIO) in pharmaceutical formulations. The optimum running buffer composition was found to be 75 mmol/L phosphate buffer containing 30% acetonitrile (ACN) at pH 4.0. T...

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Bibliographic Details
Main Authors: Maymonah K. I. AlThikrallah, Abubakr M. Idris, Abdalla Ahmed Elbashir, Rafea E. E. Elgorashe, Alyah Buzid, Ahmed O. Alnajjar
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
capillary electrophoresis
pioglitazone
metformin
diabetes mellitus
pharmaceutical formulations
analytical method validation
Online Access:https://www.mdpi.com/1420-3049/28/3/1184

Internet

https://www.mdpi.com/1420-3049/28/3/1184

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