A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders

A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders

Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function. During a neuropathological challenge, such as during human immunodeficiency virus (HIV)-1 infection or (METH)amphetamine exposure, astro...

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Bibliographic Details
Main Authors: Jessica Proulx, Satomi Stacy, In-Woo Park, Kathleen Borgmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neuroscience
Subjects:
mitochondria-associated ER membranes
unfolded protein response
metabolic function
neuroinflammation
astrogliosis
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.906651/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.906651/full

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