Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and neuroinflammation. The presence of reactive glia correlates with deposition of pathological α-syn in early-stage PD. Thus...

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Bibliographic Details
Main Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Neurobiology of Disease
Subjects:
Glia
Microglia
Astrocyte
Alpha-synuclein
Neuroinflammation
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612400010X

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http://www.sciencedirect.com/science/article/pii/S096999612400010X

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