Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L

Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L

Human cytomegalovirus (CMV) utilizes different glycoproteins to enter into fibroblast and epithelial cells. A trimer of glycoproteins H, L, and O (gH/gL/gO) is required for entry into all cells, whereas a pentamer of gH/gL/UL128/UL130/UL131A is selectively required for infection of epithelial, endot...

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Bibliographic Details
Main Authors: Li He, Scott Taylor, Catherine Costa, Irene Görzer, Julia Kalser, Tong-Ming Fu, Daniel Freed, Dai Wang, Xiaohong Cui, Laura Hertel, Michael A. McVoy
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
cytomegalovirus
neutralizing antibody
hyperimmune globulin
glycoprotein O
polymorphism
immune evasion
Online Access:https://www.mdpi.com/1999-4915/14/7/1508

Internet

https://www.mdpi.com/1999-4915/14/7/1508

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