Cytoplasmic translocation of nuclear LSD1 (KDM1A) in human hepatoma cells is induced by its inhibitors

Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A at the same IC50 as that of the clinically used tranylcypromine. Here, we rep...

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Bibliographic Details
Main Authors: Suemi Yabuta, Yoshihiro Shidoji
Format: Article
Language:English
Published: Taylor & Francis 2019-06-01
Series:Hepatic Oncology
Subjects:
Online Access:https://www.futuremedicine.com/doi/10.2217/hep-2018-0008