Cytoplasmic translocation of nuclear LSD1 (KDM1A) in human hepatoma cells is induced by its inhibitors
Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A at the same IC50 as that of the clinically used tranylcypromine. Here, we rep...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis
2019-06-01
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Series: | Hepatic Oncology |
Subjects: | |
Online Access: | https://www.futuremedicine.com/doi/10.2217/hep-2018-0008 |