Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes

Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes

Type 1 diabetes (T1D) is an immune-mediated disease with a strong genetic basis but might be influenced by non-genetic factors such as microbiome development that “programs” the immune system during early life as well. Factors influencing pathogenesis, including a leaky intestinal mucosal barrier, a...

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Bibliographic Details
Main Authors: Ling Xiao, Belinda van’t Land, Wouter R. P. H. van de Worp, Bernd Stahl, Gert Folkerts, Johan Garssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
gut microbiota
mucosal immunity
tolerogenic dendritic cells
short-chain fatty acids
human milk oligosaccharides
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01219/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01219/full

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