A nanoparticle vaccine displaying varicella-zoster virus gE antigen induces a superior cellular immune response than a licensed vaccine in mice and non-human primates

A nanoparticle vaccine displaying varicella-zoster virus gE antigen induces a superior cellular immune response than a licensed vaccine in mice and non-human primates

Herpes zoster (HZ), also known as shingles, remains a significant global health issue and most commonly seen in elderly individuals with an early exposure history to varicella-zoster virus (VZV). Currently, the licensed vaccine Shingrix, which comprises a recombinant VZV glycoprotein E (gE) formulat...

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Bibliographic Details
Main Authors: Yuanyuan Li, Siyu Tian, Yuanbao Ai, Zhulong Hu, Chao Ma, Meijuan Fu, Zhenqian Xu, Yan Li, Shuyun Liu, Yongjuan Zou, Yu Zhou, Jing Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
shingles vaccine
gE
NP
VLP
tag/catcher system
CMI
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1419634/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1419634/full

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