TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration
Growth and destruction are central components of the neuronal injury response. Injured axons that are capable of repair, including axons in the mammalian peripheral nervous system and in many invertebrate animals, often regenerate and degenerate on either side of the injury. Here we show that TIR-1/...
Main Authors: | Victoria L Czech, Lauren C O'Connor, Brendan Philippon, Emily Norman, Alexandra B Byrne |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/80856 |
Similar Items
-
Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
by: Huilan Zeng, et al.
Published: (2024-02-01) -
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
by: Arnau Llobet Rosell, et al.
Published: (2022-12-01) -
SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration
by: Laura K. Finnegan, et al.
Published: (2022-01-01) -
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
by: Veselina Petrova, et al.
Published: (2021-02-01) -
Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment
by: Ana Rita Costa, et al.
Published: (2020-08-01)