Identification of phytomolecules as isoform and mutation specific PI3K-α inhibitor for protection against breast cancer using e-pharmacophore modeling and molecular dynamics simulations

Identification of phytomolecules as isoform and mutation specific PI3K-α inhibitor for protection against breast cancer using e-pharmacophore modeling and molecular dynamics simulations

Abstract PI3K-α mutation plays a critical role in cancer development, notably in breast cancer, particularly within HR + /HER2- subtypes. These mutations drive tumor growth and survival by activating the PI3K/AKT/mTOR pathway, which is essential for cell proliferation and survival. Our research aime...

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Bibliographic Details
Main Authors: Ajay Mili, Sumit Birangal, Jyothi Giridhar, Krishnadas Nandakumar, Richard Lobo
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Chemistry
Subjects:
Breast cancer
PI3K-α inhibitor
Natural compounds
E-Pharmacophore
Molecular Dynamics
Online Access:https://doi.org/10.1186/s13065-024-01317-w

Internet

https://doi.org/10.1186/s13065-024-01317-w

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