Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease

Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease

Abstract Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic Parkinson’s disease (PD). The pathological features of PD patients with LRRK2 variants differ. Here, we report an autopsy case harboring the LRRK2 G2385R, a risk variant for PD occurring mainly in Asian...

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Bibliographic Details
Main Authors: Toshiki Tezuka, Daisuke Taniguchi, Mariko Sano, Tomoyo Shimada, Yutaka Oji, Taiji Tsunemi, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Jun Ogata, Kahori Shiba-Fukushima, Manabu Funayama, Kenya Nishioka, Yuzuru Imai, Nobutaka Hattori
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00367-y

Internet

https://doi.org/10.1038/s41531-022-00367-y

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