SIRT6 is a key regulator of mitochondrial function in the brain

SIRT6 is a key regulator of mitochondrial function in the brain

Abstract The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration. Here, we combined transcriptomics and metabolomics approaches to characterize t...

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Bibliographic Details
Main Authors: Dmitrii Smirnov, Ekaterina Eremenko, Daniel Stein, Shai Kaluski, Weronika Jasinska, Claudia Cosentino, Barbara Martinez-Pastor, Yariv Brotman, Raul Mostoslavsky, Ekaterina Khrameeva, Debra Toiber
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05542-w

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https://doi.org/10.1038/s41419-022-05542-w

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