Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer

Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer

Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to study pancreatic ductal adenocarcinoma evolution an...

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Bibliographic Details
Main Authors: Haochen Zhang, Elias-Ramzey Karnoub, Shigeaki Umeda, Ronan Chaligné, Ignas Masilionis, Caitlin A. McIntyre, Palash Sashittal, Akimasa Hayashi, Amanda Zucker, Katelyn Mullen, Jungeui Hong, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36344-z

Internet

https://doi.org/10.1038/s41467-023-36344-z

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