Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine

Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine

Introduction: Since their introduction, adjuvanted recombinant subunit vaccines against COVID-19 have played a pivotal role in protecting global populations. Optimizing the immune response’s quality, amplitude, and durability to these vaccines depends on the appropriate adjuvant choice and dose in c...

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Bibliographic Details
Main Authors: William R. Lykins, Jeroen Pollet, Jessica A. White, Brian Keegan, Leroy Versteeg, Ulrich Strych, Wen-Hsiang Chen, Raodoh Mohamath, Gabi Ramer-Denisoff, Sierra Reed, Samuel Beaver, Alana Gerhardt, Emily A. Voigt, Mark A. Tomai, Robert Sitrin, Robert K. M. Choy, Frederick J. Cassels, Peter J. Hotez, Maria Elena Bottazzi, Christopher B. Fox
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Drug Delivery
Subjects:
receptor binding domain
adjuvant formulation
SARS-CoV-2
vaccine development
toll-like receptor
bivalent vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2024.1342518/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2024.1342518/full

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