Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity

Abstract Recent genetic evidence has linked WNT downstream mutations to fat distribution. However, the roles of WNTs in human obesity remain unclear. Here, the authors screen all Wnt‐related paracrine factors in 1994 obese cases and 2161 controls using whole‐exome sequencing (WES) and identify that...

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Bibliographic Details
Main Authors: Yingkai Sun, Juan Zhang, Jie Hong, Zhongyun Zhang, Peng Lu, Aibo Gao, Mengshan Ni, Zhiyin Zhang, Huanjie Yang, Juan Shen, Jieli Lu, Wenzhi Xue, Qianqian Lv, Yufang Bi, Yi Arial Zeng, Weiqiong Gu, Guang Ning, Weiqing Wang, Ruixin Liu, Jiqiu Wang
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
obesity
pathogenic gene
RSPO1
thermogenesis
whole‐exome sequencing
Wnt signaling
Online Access:https://doi.org/10.1002/advs.202207152

Internet

https://doi.org/10.1002/advs.202207152

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