PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.

PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme and transcription factor that is involved in inflammatory response, but its role in T cell response remains largely unknown. We show here that PARP-1 regulates the suppressive function of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Sp...

Full description

Bibliographic Details
Main Authors: Pin Zhang, Takashi Maruyama, Joanne E Konkel, Brittany Abbatiello, Brian Zamarron, Zhao-qi Wang, Wanjun Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747222?pdf=render

Internet

http://europepmc.org/articles/PMC3747222?pdf=render

Similar Items