Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function

It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation and function. Moreover, changes in PM lipid composition affect the biophysical properties of lipid rafts and have a...

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Bibliographic Details
Main Authors: George A. Robinson, Kirsty E. Waddington, Ines Pineda-Torra, Elizabeth C. Jury
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
T-cells
lipid rafts
cholesterol
glycosphingolipids
fatty acids
nuclear receptors
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01636/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01636/full

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