Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling

Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling

Depression is a prevalent psychiatric disorder. Microglial state transition has been found in many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII, Gps) are saponin extracts isolated from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino that exert...

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Bibliographic Details
Main Authors: Li-Hua Cao, Yuan-Yuan Zhao, Ming Bai, David Geliebter, Jan Geliebter, Raj Tiwari, Hong-Juan He, Zhen-zhen Wang, Xing-Yuan Jia, Jin Li, Xiu-Min Li, Ming-San Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
gypenosides
depression-like behaviors
TLR4/MyD88/NF-κB signaling
microglial state transition
microglial phenotypes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.838261/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.838261/full

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