Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Abstract Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway, but its role in sepsis‐induced muscl...

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Bibliographic Details
Main Authors: Lukas Zanders, Melanie Kny, Alexander Hahn, Sibylle Schmidt, Sebastian Wundersitz, Mihail Todiras, Ines Lahmann, Arnab Bandyopadhyay, Tobias Wollersheim, Lars Kaderali, Friedrich C. Luft, Carmen Birchmeier, Steffen Weber‐Carstens, Jens Fielitz
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
gp130
IL‐6 signalling
Inflammation
Sepsis
Muscle atrophy
Intensive care unit acquired weakness
Online Access:https://doi.org/10.1002/jcsm.12867

Internet

https://doi.org/10.1002/jcsm.12867

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