Single cell analysis of the localization of the hematopoietic stem cells within the bone marrow architecture identifies niche-specific proliferation dynamics

Single cell analysis of the localization of the hematopoietic stem cells within the bone marrow architecture identifies niche-specific proliferation dynamics

IntroductionHematopoietic stem cells (HSC) reside in the bone marrow (BM) in specialized niches which provide support for their self-replication and differentiation into the blood cells. Recently, numerous studies using sophisticated molecular and microscopic technology have provided snap-shots info...

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Bibliographic Details
Main Authors: Maria Mazzarini, Francesca Arciprete, Orietta Picconi, Mauro Valeri, Paola Verachi, Fabrizio Martelli, Anna Rita Migliaccio, Mario Falchi, Maria Zingariello
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Medicine
Subjects:
hematopoietic stem cells
GFP reporter
quantitative microscopy
microenvironment
aging
adipocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1166758/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1166758/full

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