Quantitative structure–activity relationship based modeling of substituted indole Schiff bases as inhibitor of COX-2

Quantitative structure–activity relationship based modeling of substituted indole Schiff bases as inhibitor of COX-2

We have performed the quantitative structure activity relationship (QSAR) study for N-1 and C-3 substituted indole shiff bases to understand the structural features that influence the inhibitory activity toward the cyclooxygenase-2 (COX-2) enzyme. The calculated QSAR results revealed that the drug a...

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Bibliographic Details
Main Authors: Amrita Dwivedi, Ajeet Singh, A.K. Srivastava
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Journal of Saudi Chemical Society
Subjects:
COX-2 inhibitors
Physicochemical parameters
QSAR
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610313000100

Internet

http://www.sciencedirect.com/science/article/pii/S1319610313000100

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