Disruption of Axonal Transport in Motor Neuron Diseases

Disruption of Axonal Transport in Motor Neuron Diseases

Motor neurons typically have very long axons, and fine-tuning axonal transport is crucial for their survival. The obstruction of axonal transport is gaining attention as a cause of neuronal dysfunction in a variety of neurodegenerative motor neuron diseases. Depletions in dynein and dynactin-1, moto...

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Bibliographic Details
Main Authors: Gen Sobue, Fumiaki Tanaka, Shinsuke Ishigaki, Kensuke Ikenaka, Masahisa Katsuno, Kaori Kawai
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:International Journal of Molecular Sciences
Subjects:
axonal transport
dynactin-1
dynein
kinesin
neurofilament
motor neuron
amyotrophic lateral sclerosis
spinal and bulbar muscular atrophy
spinal muscular atrophy
hereditary spastic paraplegia
Online Access:http://www.mdpi.com/1422-0067/13/1/1225/

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http://www.mdpi.com/1422-0067/13/1/1225/

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