Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer

Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer

The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for immune evasion of cancer cells, and this complex is one of the main targets of immunotherapies used in oncology. Treatment using im...

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Bibliographic Details
Main Authors: Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Piotr Ciura, Claire Battin, Peter Steinberger, Katarzyna Magiera-Mularz, Grzegorz Dubin, Adam Kulesza, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Translational Oncology
Subjects:
PD-1 - Programmed cell death 1
PD-L1 - Programmed cell death 1 - ligand 1
Immune checkpoint inhibitor
Disulfide-linked peptide
Immunotherapy
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324000184

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http://www.sciencedirect.com/science/article/pii/S1936523324000184

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