Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

We have developed nanoballs, a biocompatible self-assembly nano-vector based on electrostatic interactions that arrange anionic macromolecules to polymeric nanomaterials to create nucleic acid carriers. Nanoballs exhibit low cytotoxicity and high transfection efficiently in vivo. This study investig...

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Bibliographic Details
Main Authors: Masahito Hara, Yoshinori Sumita, Yukinobu Kodama, Mayumi Iwatake, Hideyuki Yamamoto, Rena Shido, Shun Narahara, Takunori Ogaeri, Hitoshi Sasaki, Izumi Asahina
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Materials
Subjects:
bone augmentation
in vivo gene delivery
gene-activated matrix
plasmid vector
self-assembly nano-device
Online Access:https://www.mdpi.com/1996-1944/14/22/7097

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https://www.mdpi.com/1996-1944/14/22/7097

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