Estimation Aspects of the Michaelis–Menten Model

This paper studies the Michaelis–Menten model (MM), which plays an important role in pharmacokinetics, from a theoretical as well as a computational point of view. An analytical method for the nonlinear least squares estimation of the MM is introduced. It is proved that the MM model has not a uniqu...

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Bibliographic Details
Main Authors: Thomas L. Toulias, Christos P. Kitsos
Format: Article
Language:English
Published: Instituto Nacional de Estatística | Statistics Portugal 2016-04-01
Series:Revstat Statistical Journal
Subjects:
Online Access:https://revstat.ine.pt/index.php/REVSTAT/article/view/181