Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt–mTOR pathway

Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt–mTOR pathway

Abstract Glioma is the most common and aggressive primary brain tumor in adults with high morbidity and mortality. Rapid proliferation and diffuse migration are the main obstacles to successful glioma treatment. Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses a sig...

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Bibliographic Details
Main Authors: Huaqing Chen, Tong Zhu, Xiaojie Huang, Wenshuang Xu, Zemin Di, Yuyang Ma, Min Xue, Sixing Bi, Yujun Shen, Yongqiang Yu, Yuxian Shen, Lijie Feng
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Pharmacology Research & Perspectives
Subjects:
autophagy
glioma
mTOR
tumorigenicity
xanthatin
Online Access:https://doi.org/10.1002/prp2.1041

Internet

https://doi.org/10.1002/prp2.1041

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