HupB, a nucleoid-associated protein, is critical for survival of Mycobacterium tuberculosis under host-mediated stresses and for enhanced tolerance to key first-line antibiotics

HupB, a nucleoid-associated protein, is critical for survival of Mycobacterium tuberculosis under host-mediated stresses and for enhanced tolerance to key first-line antibiotics

To survive and establish its niche, Mycobacterium tuberculosis (Mtb) engages in a steady battle against an array of host defenses and a barrage of antibiotics. Here, we demonstrate that Mtb employs HupB, a nucleoid-associated protein (NAP) as its key player to simultaneously battle and survive in th...

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Bibliographic Details
Main Authors: Niti Singh, Nishant Sharma, Padam Singh, Manitosh Pandey, Mohd Ilyas, Lovely Sisodiya, Tejaswini Choudhury, Tannu Priya Gosain, Ramandeep Singh, Krishnamohan Atmakuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Microbiology
Subjects:
HupB
Hlp
stress
antibiotics
SD1
Mycobacterium tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.937970/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.937970/full

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