Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

Abstract Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is involved in PE development is not yet u...

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Bibliographic Details
Main Authors: Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Medicine
Subjects:
A2M
PE
TGFβ1
Uterine spiral artery remodeling
Placental vascularization
Online Access:https://doi.org/10.1186/s12916-023-02807-9

Internet

https://doi.org/10.1186/s12916-023-02807-9

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